Nature

The Hardy-Weinberg Principle

The Hardy-Weinberg theorem characterizes the distributions of genotype frequencies in populations that are not evolving, and is thus the fundamental null model for population genetics. Under the ...
ascopubs.org

Leveraging high variant allele frequencies (VAF) of DNA damage repair (DDR) mutations (muts) in liquid biopsy (LBx) as a surrogate for germline testing: Implications for ...

Age-related germline landscape of endometrial cancer: Focus on early-onset cases. Estimated prevalence of pathogenic variants in patients with breast, colon, and/or endometrial cancer who do not meet ...
ascopubs.org

Impact of variant allele frequency (VAF) of TP53 alterations and Signatera circulating tumor DNA (ctDNA) monitoring for patients (pts) with advanced urothelial carcinoma (aUC ...

Comprehensive investigation of CPSF3's role in the progression of bladder cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium. This abstract does not include a ...
National Academies of Sciences%2c Engineering%2c and Medicine

The Evaluation of Forensic DNA Evidence

Much of the controversy about the forensic use of DNA has involved population genetics. In this chapter, we first explain the principles that are generally applicable. We then consider the special ...