Naturally occurring molecule shown to restore memory function in Alzheimer's models

Singapore has one of the highest life expectancies in the world, yet many individuals spend almost a decade in poor health ...
Technology Networks

Naturally Occurring Metabolite Can Restore Memory in Alzhiemer's

Calcium alpha-ketoglutarate, a naturally occurring metabolite, can restore key memory-related brain functions that have been disrupted in Alzheimer’s disease.
Nature

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet, a mechanistic understanding of what ...
JSTOR Daily

Oncometabolite D-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

This is a preview. Log in through your library . Abstract Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a ...
Nature

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Glutamine metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the underlying mechanisms regulated by glutamine metabolism to ...