The presence of axonal transections in patients with very short disease duration implies that axonal transection occurs in MS lesions at a very early stage of the disease. These 2 studies in ...

How does axonal loss, a hallmark of multiple sclerosis, occur? A study in this issue implicates histone deacetylase 1 (HDAC1), better known for regulating DNA transcription, in such axon degeneration.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 24 (Dec., 1990), pp. 9828-9832 (5 pages) Whether compression nerve injury is due to ischemia, direct ...