Obesity, insulin resistance and diabetes are associated with raised plasma concentrations of C3 and C4. 16, 17, 18, 19 Several links of evidence suggest that C3 also ...

Please provide your email address to receive an email when new articles are posted on . Low complement levels prior to pregnancy are associated with an increased risk for adverse outcomes, including ...

Your complement system consists of a group of important proteins in your bloodstream. These proteins help your immune system fight off harmful invaders, such as bacteria, and other foreign substances.

A complement C4 (also known as a complement component 4, or simply C4) is a test to measure the level of C4 proteins you have in your blood. These proteins play a role in how your immune system ...

ARO-C3 treatment led to deep and sustained reductions in alternative pathway complement activity and proteinuria. ARO-C3, an investigational RNA interference-based therapy targeting hepatic expression ...

Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is ...

Complement 3 glomerulopathy (C3G) is a glomerular disorder marked by dominant deposition of the C3 complement component within the glomeruli, with minimal or no presence of immunoglobulins and no ...