News Medical

How to identify FRET artifacts in flow cytometry staining panels

This article is based on a poster originally authored by Sanaz Koosha, Manpreet Singh, Eva Van Lombergen, Bieke Soen, Matthias De Decker, Leen Catrysse and Nithianandan Selliah. Precise ...
Nature

Tuning TCR complex recruitment to the T cell antigen coupler (TAC) enhances TAC-T cell function

The T cell antigen coupler (TAC) receptor is a novel synthetic receptor designed to maximize the therapeutic potential of T cells in the absence of tonic signaling or receptor-related toxicities.
Nature

Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss

T cells recognize antigens presented through peptide:MHC complexes using surface-expressed, heterodimeric αβT cell receptors (TCRs). As the TCR lacks intrinsic kinase activity, signals initiated by ...
EurekAlert!

Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity (IMAGE)

LAG-3 exerts its inhibitory function by undergoing phase separation with the CD3ε subunit of the TCR/CD3 complex; Enhancing the cis-proximity between LAG-3 and TCR through a LAG-3/TCR bispecific ...