The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When ...

For millions of people, statins are a daily safeguard against heart attacks and strokes. But for about 1 in 10 users, these widely prescribed drugs come with an unexpected tradeoff—persistent muscle ...

Mitochondrial calcium signaling is crucial for energy metabolism and calcium homeostasis, but monitoring it accurately is challenging due to pH fluctuations. Existing GECIs are often sensitive to pH ...

The field of mathematical modelling of calcium signalling dynamics has evolved into an essential interdisciplinary area that bridges applied mathematics, computational simulation and cell biology.

Calcium signalling is a pivotal regulatory mechanism in ciliated protozoa, orchestrating a myriad of cellular processes from ciliary beating to membrane trafficking. Recent studies have illuminated ...

Cerebral blood delivery depends on mechanisms such as electrical signaling, which propagates through capillary networks to upstream arterioles to deliver blood, and calcium signaling, which fine-tunes ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, is ...

Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...

A new method exposes key details of the mechanism behind calcium signaling in prokaryotes for the first time. Working in a Listeria monocytogenes model, researchers from Umeå University (Sweden) led ...

Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be ...

Emerging research suggests milk fever may be less about calcium deficiency and more about how inflammation and metabolism ...