In cells, CENP-A binds to histone H4 and HJURP before it is incorporated into the centromere. The previous model proposed that HJURP recognizes Mis18C and CENP-A is incorporated into the centromere ...

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive structural supports. But a new study reveals they play a far more active signaling ...

Scientists have uncovered how brewer’s yeast developed its unusually tiny centromeres, the DNA regions that guide chromosome ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

Due to their repetitive and complex DNA sequences, centromeres have been viewed as the "black boxes" of the genome for decades. Often overlooked in sequencing projects but playing a critical role in ...

Advancements in genome sequencing have challenged the long-standing belief that the position of the centromere in the chromosome is fixed. Researchers from Okayama University, Japan, have analyzed ...

Researchers from the Kops group in collaboration with researchers from the University of Edinburgh, made a surprising new discovery in the structure of the centromere, a structure that is involved in ...

If I asked you, dear reader, to come up with a shortlist of the most monumental scientific achievements of the last century, chances are the Human Genome Project (HGP) would appear somewhere on that ...

The evidence of premature centromere division of the metaphase chromosomes as a new prognostic cytogenetic marker of infant's acute lymphoblastic leukemia (ALL) is suggested. The frequency of PCD ...