CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

The organisation of the genome in three-dimensional space is a fundamental aspect of gene expression programmes that underlie cell fate and plasticity. Understanding 3D genome organisation is ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA – its genome – and segregate it equally ...

Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...