Integrins are widely expressed cell-adhesion molecules with key roles in thrombosis, inflammation and cancer, and as a result are important drug targets. Inhibitors of αIIbβ3, α4 and αLβ2 integrins ...
Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...
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