BRCA1 genetic variant to predict survival in metastatic colorectal cancer (mCRC) patients (pts) treated with FOLFIRI/bevacizumab (bev): Results from phase III TRIBE and FIRE-3 trials. Background: ...
Predictors of the survival for platinum-refractory head and neck squamous cell carcinoma by using contrast-enhanced magnetic resonance imaging. [1] One patient was a nasopharyngeal carcinoma patient ...
Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2 ...
LA JOLLA, CA – October 31, 2012 – Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical ...
Kinases have been intensively investigated as drug targets for the past 30 years, with 38 kinase inhibitors approved to date 1. These drugs are predominantly multitargeted receptor tyrosine kinase ...
At the Albert Einstein College of Medicine, Evripidis Gavathiotis, PhD, and colleagues have been developing inhibitors of Bcl-2-associated X protein (BAX), a molecule known to stimulate apoptosis. In ...
Scientists at the University of Texas MD Anderson Cancer Center say have discovered a novel function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM). MCAD ...
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