Breast cancer tissue microarray slides were obtained from the Cooperative Breast Cancer Tissue Resource (CBCTR), funded by the National Cancer Institute (NCI). The tissue microarrays included 192 ...

Alagille syndrome (ALGS) is a rare, multisystem genetic disorder most commonly caused by haploinsufficiency of the JAG1 gene, leading to reduced JAG1 protein function and impaired development of ...

Researchers define the role of a jagged ligand, JAG1, in cancer cells' ability to differentiate and metastasize, making them harder to track down and eliminate. A jagged little protein appears to be ...

Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver where ...

Researchers at the Karolinska Institute have used DNA origami to demonstrate how an important cell receptor can be activated in a previously unknown way. The new study provides insight into how the ...

Mose model shows that SOX9 gene influences the severity Alagille syndrome. Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and ...

Alagille syndrome is a rare genetic disorder. While most cases are diagnosed in infancy or early childhood, milder forms can remain unrecognized until adolescence or even adulthood. Alagille syndrome ...