Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

Aim: This study examines the absolute quantification of particle uptake into cells. Methods: We developed a novel method to analyze stacks of confocal fluorescence images of single cells interacting ...

Ultrasound-mediated nanobubbles improve cancer therapy by softening tumors, enhancing lipid nanoparticle distribution, and ...

Researchers developed a DNA barcoding assay to measure nanoparticle cargo escape in living organisms, enabling a new class of lipid nanoparticles for more efficient gene editing.

Explore the future of gene therapy delivery with lipid nanoparticles. Learn how they can transform treatments for various diseases.

Lipid nanoparticles (LNPs) act as carriers for mRNA and CRISPR payloads across a wide range of therapeutic applications, from cancer to inflammatory and genetic diseases. The same delivery system used ...

Hydration energetics may become a central tool in engineering safer, longer-circulating, and more effective nanoparticle therapies.

How can a drug be delivered exactly where it is needed, while limiting the risk of side effects? The use of nanoparticles to encapsulate a drug to protect it and the body until it reaches its point of ...

In vivo generation of transient FAPCAR T cells improves cardiac function after injury. CAR T therapy, a “living drug,” traditionally involves isolation and purification of T cells outside the body.

The 3D reconstruction of the cellular ROI employed by Particle-in-cell-3D (see the 'Routine 1: visualization of the intracellular distribution of particles' section) includes the formation of a ...