How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca 2+ flux in the target cell, which triggers a ...

It describes the cellular and biochemical mechanisms that are responsible for protecting cytotoxic T lymphocytes and natural killer cells from endogenous cytotoxic perforin and granzymes. Structural ...

Scientists have seen the human immune system's assassin -- a protein called perforin -- in action for the first time. The researchers used powerful electron microscopes to study the mechanism that ...

After eight years of work, researchers have unearthed what has been a well-kept secret of our immune system's success. The findings offer an explanation for how specialized immune cells are able to ...

Pore-forming proteins play critical roles in pathogenic attack and immunological defence. The membrane attack complex/perforin (MACPF) group of homologues represents, with cholesterol-dependent ...

In a medical breakthrough scientists have found a protein called perforin that kills rogue cells in the human body especially the ones causing cancer. The team comprising of experts from Melbourne and ...

“Not a week goes by when I don’t get a call from someone on the planet asking, ‘Does this seem like it’s it?’” Cron said. The “it” in question goes by several names in the medical literature. But the ...

Dr. Eckhard Podack, a distinguished professor at Sylvester Cancer Comprehensive Center, worked on lung cancer vaccines and chaired the Department of Microbiology and Immunology at the University of ...