Peripheral sensitization refers to the lowering of the threshold of excitability of sensory neurons, which leads to an amplified reaction to a specific external stimulus. Sensitization can be mediated ...

There are the unfortunate patients who develop pain hypersensitivity. These patients have a pain threshold that is lower than normal, and the duration of the pain response can become long-lived. There ...

Neuropathic pain arises directly from a lesion or disease affecting the somatosensory system. Our current knowledge on the mechanisms of neuropathic pain comes largely from animal models of peripheral ...

Despite extensive research, the pathogenesis of pain in fibromyalgia syndrome is incompletely understood. Fibromyalgia pain is consistently felt in deep tissues including ligaments, joints and muscles ...

Injury to tissue and nerves initiates an inflammatory response that is intended to contain pathogens, clear damaged tissues and promote repair. As one of the five cardinal signs of inflammation, pain ...

Pain represents the cardinal symptom of osteoarthritis, yet its intensity, quality, and impact vary dramatically among ...