The journey by which proteins navigate their energy landscapes to their native structures is complex, involving (and sometimes requiring) many cellular factors and processes operating in partnership ...

E. Coli-Based Refolding Technology Relies on Antibiotic- and Phage-Free Plasmid System Wacker Biotech and Fresenius Medical Care Adsorber Tec last month reached a key milestone in their collaboration ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

PHILADELPHIA – While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation ...

A new study has described a potential mechanism that could help explain why some proteins refold in a different pattern than expected. The research showed that a type of misfolding, called ...

This new pattern was described as "stretched-exponential refolding kinetics," but the structural mechanism that explained this difference remained a mystery - until now. The research team hypothesized ...

Controlling protein structure is crucial in the production of detergents and cosmetics. Up to now we have not had a clear understanding of how soap molecules and proteins work together to change ...