Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health consequences, with recurrent ...

Activated T cells acquire the ability to home to extralymphoid sites, including the lungs, skin, gastrointestinal tract and central nervous system, where they can enter extravascular tissues even in ...

Selectins are a family of cell adhesion molecules that participate in the early phases of leukocyte–endothelium interactions. They are required for the trafficking of innate immune system cells, T ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not include a full text component.

The gastrointestinal tract represents the largest reservoir of eosinophils within the body. In the gut, eosinophils play an important role in several inflammatory disorders (1). During these ...

Edited by: Thomas W. Durso S.D. Rosen, C.R. Bertozzi, "The selectins and their ligands," Current Opinion in Cell Biology, 6:663-73, 1994. (Cited in more than 60 publications through April 1996) ...

The movement of leukocytes from the circulatory system to the site of inflammation and subsequent attachment forms an integral part of the innate immune system. The three steps of leukocyte rolling, ...