Exponential signal amplification is achieved when a single molecule of analyte initiates a chain reaction in which a dendrimer releases a coloured 'reporter' molecule, and ultimately four further ...

Cells naturally process external signals through intricate genetic circuits, enabling the adaptation to diverse environments. These circuits rely on complex, nonlinear interactions among genes and ...

Flow cytometry, invented in the 1950s, uses antibodies linked to fluorescent probes to detect cell surface and intracellular proteins. Although able to achieve single-cell sensitivity, the method is ...

TSA has been applied to improve immunohistochemistry, in situ hybridization and other protocols while using pre-existing imaging techniques, such as microscopes. In TSA, horseradish peroxidase reacts ...

Chemical sensors whose signals can be amplified by various triggers hold huge potential in multidisciplinary sciences. However, developing such systems was considered a highly challenging task, until ...

Tyramide Signal Amplification (TSA) is an immunohistochemistry technique designed to detect and quantify molecules such as proteins and nucleic acids. It is also referred to as catalyzed reporter ...