Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...

Researchers from Tokyo Medical and Dental University (TMDU) find that integrating and selectively analyzing splicing variant data can help identify genetic variations associated with complex human ...

Viral-infected cell lines are a commonly used experimental system to investigate host mechanisms and restriction factors, which inhibit viral replication and infection. In the present study, ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

Study design to create a database of transcripts, called TRAILS (TRAnscriptomic resource of Immune cells using Long-read Sequencing), from different human immune cell subsets and downstream analysis.

By finding areas of perfect matches between long RNA sequencing reads and genomic DNA, as well as borrowing information across all long RNA sequencing reads of a gene, the tool is able to identify ...

A study led by German scientists has developed a new therapeutic to treat a currently untreatable form of heart failure by targeting a splice regulator in stiffened cardiac muscle cells to render them ...

Long-read platforms that can sequence RNA molecules over 10,000 bases in length end-to-end hold great potential for use in characterizing variations in the transcriptome. But while these technologies ...

ESPRESSO overcomes the limitations of error-prone long-read RNA sequencing, providing a useful resource to study transcriptome variation. Long-read RNA sequencing platforms could reveal variations in ...