The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding ...

Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal ...

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely ...

Cryo-electron microscopy (cryo-EM) was used by researchers at St. Jude Children's Research Hospital to capture the first 3D structure of the entire SPOP assembly. The findings were published in the ...

Multiple studies have determined that speckle-type POZ protein (SPOP) could suppress tumorigenesis in several types of human malignancies, including prostate, lung, gastric, liver, colon, and ...

When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such as the NUP98 fusion oncoprotein, which drives uncontrolled cell growth.

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely ...

The damaging effects of toxic proteins created in one inherited form of amyotrophic lateral sclerosis (ALS) are mediated by a protein called SPOP, according to a study published in the Proceedings of ...

Scientists have captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer. SPOP is the most mutated protein in prostate cancer and plays a role in ...