Transcriptome sequencing demonstrated that most mutations also arose in genes that were minimally expressed in the mutated allele-bearing tumor and minimally expressed in the other tumors that lacked ...

Abnormalities in the structure of chromosomes within someone’s genetic makeup are called structural chromosomal abnormalities. Robertsonian translocations are very rare structural chromosomal ...

From its beginnings two decades ago with the analysis of chromosomal translocation breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia (ALL) has now progressed to the ...

STRUCTURAL heterozygosis is the existence in heterozygous state of an interchromosomal or intrachromosomal rearrangement. Fragmentation of two chromosomes and the mutual exchange through reunion of ...

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

MONGOLISM is usually the result of trisomy of a small acrocentric chromosome in Group 21–22 in the Denver Classification. This is generally referred to as 21-trisomy. These patients have a somatic ...

Figure 1: Genomic region of the X chromosome containing the X;2 translocation breakpoint and TM4SF2 (Xp11.4 tetraspanin). Figure 3: Expression of TM4SF2 in the cell lines of the patient and detection ...

Stowers Institute researchers identified the precise fusion point of a chromosome variant that may contribute to infertility ...

chromosomal translocations associated with two types of cancer, acute myeloid leukemia and Ewing's sarcoma, have been reproduced, for the first time in human cells, by scientists. The study's authors ...

Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes ...

DOWNTOWN LOS ANGELES - Researchers at the USC Keck School of Medicine have explained how certain key mutations occur in human lymphomas - a process that has, until now, remained a mystery. The ...

Robertsonian translocation is the most common form of chromosomal translocation in humans. It means that two chromosomes, the structures that make up a person’s DNA, join together in an abnormal way.