Caspase-4 and -5 in humans, and Caspase-11 in mice have a unique role as a receptor, whereby it binds to LPS, a molecule abundant in gram negative bacteria. This can lead to the …

May 5, 2025 · Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5, and -11).

Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular …

Jul 24, 2025 · Caspase activation in programmed cell death unfolds through a coordinated cascade. Caspases are initially present in cells as inactive precursors called procaspases.

Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflammation (caspase-1, caspase …

May 19, 2025 · The conservation of caspase-mediated pathways across species highlights their essential role in development and tissue homeostasis. Recent research has identified new …

Therapeutic interventions that involve the caspase cascade have long been a goal of many pharmaceutical companies because dysregulated caspase activity (and therefore apoptosis) is …