Intestinal inflammation exacerbates endometritis through succinate ...
Jan 27, 2025 · Intestinal inflammation exacerbates endometritis through succinate production by gut microbiota and SUCNR1-mediated proinflammatory response Min Qiu a b 1 , Huafeng Geng a 1 , …
Intestinal inflammation exacerbates endometritis through succinate ...
Jan 27, 2025 · Collectively, the results suggested that dysbiosis of the gut microbiota exacerbates LPS-induced endometritis by production and migration of succinate from gut to uterine tissues via the gut …
Succinate receptor mediates intestinal inflammation and fibrosis
Jan 1, 2019 · Abstract Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. …
Succinate metabolism: a promising therapeutic target for inflammation ...
To sum up, the aforementioned findings have indicated that SUCNR1 plays a pivotal role in the immune-inflammatory response triggered by succinate. Consequently, the modulation of SUCNR1 signaling …
The role of microbial succinate in the pathophysiology of inflammatory ...
Jun 1, 2025 · Inflammatory bowel disease (IBD) is a chronic immune-mediated condition linked to gut microbiota dysbiosis and altered production of bacterial metabolites, including succinate, which is …
P001 Succinate, a gut microbiota-derived metabolite, modulates the ...
May 27, 2021 · We and others have shown that succinate plays a key role in fine-tuning of the inflammatory response, acting both as an alarmin and resolving molecule. Our hypothesis is that …
Gut flora-derived succinate exacerbates Allergic Airway Inflammation …
May 1, 2025 · Succinate, a versatile signaling metabolite produced by intestinal flora [11], operates by binding to succinate receptor 1 (SUCNR1) or influencing the succinylation of specific proteins, …
Dysregulation of gut microbiota exacerbates LPS-induced endometritis …
Consequently, the uterine injury was exacerbated through intestinal succinate, which exacerbates uterine injury by SUCNR 1-dependent promotion of NF-κB activation. Overall, our findings suggest …
Gut Microbiota and Endometriosis: Exploring the Relationship and ...
Recent studies have revealed alterations in the gut microbiota of individuals with endometriosis, including reduced diversity, microbial composition imbalances, and pathogenic bacteria. These …
Succinate pretreatment attenuates intestinal ischemia-reperfusion ...
Jul 1, 2023 · The results of pretreatment with succinate in the mouse intestinal I/R model and IEC-6 cells hypoxia-reoxygenation (H/R) model revealed a reduction in tissue damage, necroptosis and …
International Immunopharmacology | Vol 146, 27 January 2025 ...
Intestinal inflammation exacerbates endometritis through succinate production by gut microbiota and SUCNR1-mediated proinflammatory response Min Qiu, Huafeng Geng, Chenyu Zou, Xiaotong Zhao, ...