Solid-phase synthesis - Latest research and news | Nature
Nov 20, 2025 · Solid-phase synthesis is the synthesis of chemical compounds whereby the reactant molecule is chemically bound to an insoluble material and reagents are added in the solution-phase.
Total wash elimination for solid phase peptide synthesis
Dec 9, 2023 · We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Solid-phase peptide synthesis: from standard procedures to the
Dec 13, 2007 · This protocol for solid-phase peptide synthesis (SPPS) is based on the widely used Fmoc/tBu strategy, activation of the carboxyl groups by aminium-derived coupling reagents and use …
Solid-phase synthesis | Nature Chemistry
Feb 17, 2025 · Now, a new twist on solid-phase chemical synthesis has enabled rapid and simplified synthesis of pharmaceutically relevant small molecules.
Rapid and efficient protein synthesis through expansion of the native ...
Mar 29, 2018 · Although solid-phase synthesis serves as the workhorse for accessing peptides up to 50 amino acids in length, ligation technologies have underpinned protein synthesis.
Dielectrophoretic bead-droplet reactor for solid-phase synthesis
Jul 22, 2024 · Our work combines microparticle manipulation and droplet microfluidics to address a long-standing problem in solid-phase synthesis with potentially wide-ranging implications.
Template-dependent DNA ligation for the synthesis of modified
Sep 13, 2024 · Indeed, most synthetic oligonucleotides are produced by solid-phase oligonucleotide synthesis (SPOS) in which activated phosphoramidite building blocks are assembled by iterative …
Solid-phase synthesis of protein-polymers on reversible ... - Nature
Feb 27, 2018 · PARIS is a synthetic approach that allows solid-phase synthesis of grafted-from protein–polymer conjugates. PARIS generates conjugates with similar structure and function to …
Immobilized acyl-transfer molecular reactors enable the solid-phase ...
Aug 6, 2025 · Current solid-phase peptide synthesis methods struggle to incorporate sterically hindered amino acids.
DNA synthesis technologies to close the gene writing gap
Jan 23, 2023 · This Review discusses commercialized DNA synthesis technologies in the pursuit of closing the DNA writing gap.