Because CD3 is required for T-cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes …

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of signaling events.

Jul 28, 2025 · CD3 refers to a complex of proteins located on the surface of T lymphocytes, acting as a specific marker for these immune cells. This protein complex is involved in transmitting signals from …

CD3 is a multimeric protein complex comprising three different subunits: CD3δε, CD3γε, and CD3ζζ dimers. Homologous CD3δε and CD3γε are heterodimers with single extracellular immunoglobulin …

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

CD3 is not merely an accessory to the T cell receptor; it is essential for the functioning of T cells. Upon antigen recognition, CD3 aids in initiating multiple intracellular signaling cascades.

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are …

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft rejection and were …

Jun 7, 2024 · CD3 is a protein complex found on the surface of T cells, a type of white blood cell that is central to the immune response. The CD3 complex is composed of several subunits: CD3γ, CD3δ, …

Jan 1, 2018 · The CD3 proteins are type 1 TM proteins that form dimers, CD3εγ and CD3εδ, containing diverse cytoplasmic signaling motifs for inducible interaction with kinases, adaptor proteins, and …