Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is …

Dec 16, 2025 · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because …

A speedball is a combination of heroin and cocaine that is usually injected, snorted or smoked. The high produced by the stimulant effect of cocaine combined with the depressant effect of …

Mar 14, 2025 · A speedball is a combination of a stimulant (usually cocaine or methamphetamine) and a CNS depressant (typically an opioid), used simultaneously to produce an intense and …

1 day ago · Speedball will feature: Fast-paced and brutal matches. A wide range of teams and arenas, with arena-specific obstacles and abilities. A slow-motion ‘Slam Cam’ captures the …

Oct 19, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, …

Dec 2, 2025 · A “speedball” refers to combining two substances with opposing effects: a stimulant and a depressant. The classic mixture involves cocaine, a central nervous system (CNS) …

2 days ago · Rebellion Developments announced the arcade sports game, Speedball, will leave Early Access and launch for the PlayStation 5, Xbox Series X|S, and PC via Steam on …

Sep 10, 2025 · A speedball is a combination of 2 strong and potentially lethal substances: heroin and cocaine. This deadly mix of uppers and downers is often prepared by mixing powdered …

2 days ago · Speedball leaves Early Access this month, bringing the classic Bitmap Brothers series to modern gamers. Set in 2138, Speedball features brutal, fast-paced, cybernetic team …