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Why do we re-dose Ancef every 4 hours intra-operatively? Because surgical prophylaxis depends on tissue concentration, not how long the drug exists in the bloodstream. During surgery, blood loss, fluid shifts, and drug redistribution lower antibiotic levels at the surgical site faster than most people realize. This is about physiology, not preference. #plasticsurgery #anesthesia #patientsafety #medicaleducation #surgery
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